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Dołączył: 13 Gru 2010
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 Wysłany: Nie 7:40, 20 Mar 2011 Temat postu: Vitamin C, the world production, consumption and T |
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Vitamin C, the world production, consumption and Technology Development
From the VG, improve the conversion yield and product quality, (3) Japanese patent; using high molecular weight gel adsorption GluconobacterSuboxydans, the oxygen pressure in the 5O kg, will be L D-sorbitol into mountain pear sugar,[link widoczny dla zalogowanych], into income 99, and so on. 70 reported the early reaction from the three-step synthesis of glucose by the VG method, which first made an acetone glucose of glucose acetone, and then in the presence of platinum catalyst, oxidation with oxygen was an acetone -5-- glucuronide in carbonyl ester, and finally through the sulfuric acid solution and the rates of agricultural Shan oxygen (NaBH.) restored into VG. Advantages of this method is the process short, simple equipment, the value of drawback is required expensive metal platinum and sodium Shan oxygen. See further in later reports. Two-step fermentation _ t throw our country in 70 years of successful development of the legal systems of the two-step fermentation of acetone, Levin's method and chemical oxidation step = step to Pseudomonas (actually two kinds of bacteria, the so-called size bacterial synergy) bio-oxidation, get rid of a lot of organic solvent and sub-oxide sodium, reduced costs, improved working conditions and environmental protection. 4 of reference However, the cost of production has obvious advantages. The new two-step fermentation and step fermentation: 1983q ~ has emerged since the international community more than 30 patents and papers, reported that microbial synthesis by two steps from glucose (fermentation) Preparation of VC after a photo of a ketone intermediate 2 Cologne acid (2-KGA) method and the application of recombinant strain fermentation of glucose by the step directly into 2-KGA information. The new two-step fermentation and China are compared with the two-step fermentation, high pressure hydrogenation step can be reduced so that the whole production process more simplified VC. Glucose by Erwinia bacteria Acetobacter or (ErwinlaSp) can be obtained by oxidation of 2,5 - dione based gulonic acid (2 a DKGA), the latter by Corynebacterium (CorynebacteritlITl'Sp) or short bacilli (Bre-vibaeteriumSp) reduction become a keto-gulonic acid 2. Fermentation rate and the closing strains used have an important relationship. Shionogi patent; in Step 1, after fermentation is complete. If the surface of added agent (eg sodium lauryl sulfate) to kill bacteria in the original (sterilization), and then add a new strain, the fermentation step 2, this can simplify the production process into the production process _ VC. Further simplified hopes on genetic engineering in biotechnology. Has successfully Corynebacterium reductase gene was expressed in Erwinia, the recombinant strain to complete the two step step in the biosynthesis of fermentation purposes. Glucose din exhausted eleven 2-KGAErwiniaherbicola reported that a recombinant Erwinia this is not ideal because of the continuous column D-glucose oxidation of 2,5-dehydrogenase is a variety of thread DKGA station in the membrane The periplasmic enzyme. Is connected with the electronic transport and 2,5 a DKGA reductase is soluble, and NADPH binding. Alcohol present in the cytoplasm. Therefore,[link widoczny dla zalogowanych], the two processes to form an effective interface for the 2,5-DKGA transport through the cell membrane. Because of this and other reasons, should be heir this recombinant strain, yield and production capacity are very low,[link widoczny dla zalogowanych], so far. The new two-step fermentation and fermentation step can be used in production have not yet reached the technical level. DA is a large amount of VC is a wide range of longevity of six products. It was bound to continue research and development in this regard, it may be sudden warm vessel of the hair, it is worth our close attention and I agreed. For our two-step fermentation technology,[link widoczny dla zalogowanych], the deletion in the total yield is still not high enough. The second step the concentration of fermenting mash low power, indicating that there are lots of potential to be dug. Reported in recent years, a promising but far from the inquiry obtained by in vivo protein engineering of new biocatalysts parlous approach is the use of microbes as genetic engineers. l Cho in the basic principles of protein engineering is the evolution of experimental burning enzymes. Field experiments will permit a high degree of selective pressure placed on microbial chemical stability of the medium allows the formation of a new emblem of matter gradually metabolic enzymes and new way to. Gang here. Through directional selection pressure,[link widoczny dla zalogowanych], it is possible to select strains for fermentation of high concentration or high-yield strains. In addition high levels of VC and foreign production plant comparison. We are: high-performance equipment dry 【『automation and production scale are still many aspects of the whole distance, so we need to improve labor productivity and lower production costs for future work directions.
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