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 Wysłany: Czw 0:02, 17 Mar 2011 Temat postu: Twist gene expression and cell invasion in hepatoc |
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Twist gene expression and cell invasion in hepatocellular carcinoma multidrug resistance correlation
1), 1995.154:8 L20.5ThieryjP. Epithelial-mesenchymaltransitionsintumourprogressionEJ3. NatRevCancer ,2002,2:442-454 .6 ErikaRosivatz,[link widoczny dla zalogowanych], IngridBecker. katijaSpeeht,[link widoczny dla zalogowanych], eta1. DifferentialExpressionoftheEpithelial-MesenchymalTransitionRegulatorsSnail. SIP1. andTwistinGastricCancerEJ]. AmJP Ⅱ fo /, 2002,161:18811891.7 ZorzosHS. IazarisAC. K0rk0l0p0ul0urPA. MultidrugresistanceproteinsandtopoisomeraseIalphaexpressionincoloncancerlassociationwithmetastaticpotential ~ J Pathology. 2003. Aug. 35 (4) :315-8 (Series Lixin this bat) bile duct wall with massive serosal invasion in TNM staging of intrahepatic cholangiocarcinoma meaning / UenishiT / / JHepatobiliaryPancreatSurg, 2005; 12 (6) :479-83 international Cancer Association (UICC) TNM staging of bulky as the judge the prognosis of intrahepatic cholangiocarcinoma widely accepted standard, but the bile duct wall serosal invasion was not the stage to determine indicators. Liver Cancer Study Group of Japan will be included in the bile duct wall serosal invasion in TNM staging of UICC T standard. Established a new TNM staging. To study whether the bile duct wall serosal invasion of intrahepatic bile duct cancer with massive impact on survival rates in order to understand whether the new TNM staging more accurate prognosis, the authors retrospectively analyzed the 1983.1 to 2003 .12 of the 63 patients with massive resection of intrahepatic cholangiocarcinoma cases. Which combined with hepatic resection or extended liver resection in 45 cases, 11 cases of liver segment resection, and subtotal resection of hepatic segment in 2 cases, partial resection in 5 cases,[link widoczny dla zalogowanych], 3O routine hepatoduodenal ligament or liver or pancreatic artery after lymph node dissection, 23 cases of hepatic portal violations were caudate lobe resection. Tumor size 1.4 ~ 16cm (average 7cm). 30 cases of vascular invasion, 29 cases of bile duct serosal invasion occurred; 21 patients and 23 patients were lymph node and liver metastasis. Under the new TNM staging, 63 cases,[link widoczny dla zalogowanych], 3 cases of I, I of 15 cases, I of 16 cases, lVa 8 cases, IVb of the 21 cases. Cases of 63 patients with a median survival after surgery, asked for 535 days, 1,3,5-year survival rates were 61%, 4O, 33, 6 patients died during hospitalization (perioperative mortality rate was 9.5) . Log-rank analysis showed that tumor size big 3cm,[link widoczny dla zalogowanych], intrahepatic metastasis, vascular invasion, lymph node metastasis and microscopic residues on the cutting edge of cancer affect survival rates. The bile duct with or without serosal invasion in patients with postoperative survival rate of no statistical significance. Cases have occurred in terms of vascular invasion, with or without serosal invasion cases of bile duct 5-year survival rates were 0 and 17, but there was no significant difference. Instead, courage wall serosal invasion without vascular invasion cases 5-year survival rate of about 5O. Multivariate analysis showed that vascular invasion, lymph node metastasis and microscopic residual cancer is the cutting edge of independent prognostic factors. Under the new TNM staging, II 3,5 of patients survival rates were 72,54 years. The 3 patients with stage Ⅲ and 5-year survival rate was 56%, 44%. No significant difference between the two groups asked. According to the UICC's TNM staging system, 3 and 5 year survival rate of patients I were 100%, Ⅱ of the patients 73%, 62%, I of patients 38,25, IV patients were all of 7%. The survival rate of two staging a significant statistical difference (P a 0.026). On the basis of the above results that, for purposes of massive intrahepatic cholangiocarcinoma, bile duct in patients with serosal invasion was not on the impact on survival after hepatectomy. However, the bile duct wall serosal invasion as one of the criteria included in determining TNM staging was able to better determine the prognosis of different stages. (Branch review Geng Xiaoping Liu anger Excerpt)
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