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Dołączył: 21 Lut 2011
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 Wysłany: Czw 11:40, 24 Mar 2011 Temat postu: tory burch reva gbs enb kxok aoq |
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Glycoside ring phosphoryl liquid solution and the treatment of chronic heart failure in Hong Dan clinical observation of 36 cases
Agent, to correct acid-base balance and electrolyte disorders on the basis of conventional treatment,[link widoczny dla zalogowanych], symptom improvement is not obvious. Treatment on the basis of the original, pre-hospital or after admission were used digitalis, disabled after 1 week of drug digitalis, glycosides with ring phosphoryl 4O ~ 8oregOn injection into the 5% glucose solution 250mL, 1 day static drops, 20mL ~ Xiangdan injection into the 5% glucose solution 250mL, daily l ~ Jr. ,[link widoczny dla zalogowanych], Dropping speed depending on the degree of heart failure in patients with appropriate adjustments, the general 16-2O drops ,10-14d is a course of treatment,[link widoczny dla zalogowanych], a course of treatment to determine efficacy. 1.3 The evaluation standard markedly: (1) palpitations,[link widoczny dla zalogowanych], shortness of breath,[link widoczny dla zalogowanych], pulmonary rales I disappeared or significantly reduced; ECG, myocardial ischemia graphics disappear or significantly reduced heart function was improved by 2 levels. Effective: The above symptoms were relieved or reduced pulmonary rales, cardiac function l level. Invalid: After treatment, symptoms and signs unchanged. 2 Results (Table 1,2) Table 1 before and after treatment of heart failure symptoms and signs of heart failure efficacy and Table 2 Changes of cardiac function before and after treatment compared NOTE: before treatment, P <0.0196 and foreign medical CHINAFOREIGNMEDICALTREATMENT markedly in 5 patients (13. 89%), improved in 27 patients (75%), 4 cases (11.11%), the total effective rate 88.9%. 4 cases, of which 2 died. L1 cause of death as pulmonary heart disease patients with acute extensive anterior wall myocardial infarction, ventricular arrhythmia, cardiogenic shock, 1 Cor, 81-year-old, severe pulmonary infection, pulmonary heart encephalopathy. Side: After treatment, urine analysis and no abnormal liver function tests, has no other side effects. Infusion in patients during the private prosecution without discomfort. 3 Discussion of intracellular cAMP is involved in regulating metabolism and biological functions of important material, can cardiac vascular smooth muscle ATP levels, ATP can activate a series of direct or indirect protein kinase. To promote calcium influx, enhanced phosphorylation, chemical and biological regulation of cell function [2】, its pharmacological effects mild, lasting, high stability, good penetration, low side effects. It is the mechanism of heart failure treatment: (1) to promote calcium influx. Enhanced phosphorylation and promote excitement coupled with a contraction to improve myocardial contractility, increased cardiac output, muscle strength play a positive role. (2) expansion of the peripheral spot tube. Decreased cardiac ejection resistance, reduce the heart before and after the load, increase cardiac output, improve cardiac function. (3) nutrition myocardium and promoting cardiac cell survival and enhance myocardial cells against ischemia, hypoxia and anti-injury ability. (4) anti-arrhythmic, activate slow-channel, reduce sinus diastolic depolarization of automatic time and increase heart rate. Latency delay of arrhythmia, ventricular tachycardia and ventricular fibrillation to reduce the incidence of new. Xiangdan injection is the main component of Salvia and Dalbergia for the pure Chinese medicine and modern pharmacological studies confirmed; Xiangdan injection is the main component of Salvia acid, a fibrinolytic effect, the active ingredient of Salvia miltiorrhiza water-soluble acid A, There was thrombus formation of antibodies, anti-platelet aggregation. Inhibition of blood clotting, reduce blood viscosity, increased microcirculation blood flow, so that blood flow through capillaries per unit area, improved blood Thy scattered functions, and improve hypoxemia. Microcirculation, decreased pulmonary vascular resistance, decreased pulmonary artery pressure, increased cardiac output, improving heart function [4】. In the present treatment of heart failure, non-digitalis inotropic playing an increasingly important role for chronic heart failure, its effect is sometimes better than digitalis. Therefore, the control of digitalis heart failure can not be satisfied, while difficult to identify a therapeutic dose of digitalis digitalis toxicity or insufficient, no need to brave the risk of digitalis toxicity, to increase the dose of digitalis and digitalis obtained maximum effect, especially in primary health care in poor environmental conditions, the use of cAMP as such has a strong heart injection of non-digitalis inotropic effect more appropriate and safe.
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