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,[link widoczny dla zalogowanych], 1994) ¨ for diagnosis. Diagnosis of AD, particularly noteworthy is that the patient's cognitive and other changes relative to its onset before there is a significant change, and this change has affected the normal life. For example, we can not simply say that a patient is the AD patients with Down syndrome. Based on these criteria the researchers developed a series of mental ability test for clinical diagnosis, but the diagnosis of AD,[link widoczny dla zalogowanych], previously only by autopsy. Now researchers have passed these tests and imaging using a combination of means to more accurately diagnose AD patients. Commonly used to diagnose AD psychological tests are: 1) Mini-mental state examination (Mini-MentalStateExamination-MMSE); _l2) Blessed Dementia Scale (Bles, sedDementiaScale-BDS); 【14] 3) Hasegawa Dementia Scale (HasegawaDementiaScale -HDS); 4) Alzheimer Disease Assessment Scale (Alzheimer'SDiseaseAssessmentScale-ADAS) t6]; 5) 7 分钟 cognitive neurological screening schedule (SevenMinuteNeurocognitiVeScreeningBattery) iv. By imaging techniques,[link widoczny dla zalogowanych], such as CT (computerizedtomography), MRI (magneticresonanceimaging) or PET (positron-emissiontomography), researchers have found that most of the brain in AD patients with amyloid (amy1oldprotein) precipitation anomalies: if amyloid was found between cells in the brain called While in the interior of cells called protein deposition in the brains of AD patients with frontal and temporal lobe is particularly evident. Temporal lobe is usually considered to information storage, whereas the frontal lobe also plays a key role in the formation of personality: whether there has clinically senile plaques and neurofibrillary tangles diagnosis as an important means of AD. Recently, researchers have clinical symptoms of AD and the first pathological changes (preclinicalstage) showed great interest, that AD is diagnosed the more likely the earlier the patient intervention and treatment. Experts have recently identified a close relationship with the AD (or even may be an early form of AD) a new memory impairment: mild cognitive impairment (mildcognitiveimpairment-MCI) MCI/1l Division in normal aging caused by forgotten . It is mainly for poor test scores and recall the words repeatedly forget important events. About 40% of the MCI in the 3-year period to develop into the first AD patients = 18iAD clinical pathological changes include first entorhinal cortex and hippocampus of neurofibrillary tangles I9_ and followed with the language,[link widoczny dla zalogowanych], spatial orientation, attention and cognitive speed and other related new cortical lesions (8 to amyloid deposition). [18,20] Rapoport and other techniques to identify AD patients by PET at rest before the frontal lobe, parietal lobe, and have shown a pattern of abnormal metabolism. When involved in cognitive activities, patients are still capable of mild symptoms by increasing blood flow to fill the gap almost impossible in severe cases: 2 ¨ Bookheimer and so on through functional magnetic resonance imaging (functionalmagneticresonanceimaging-fMRI) means further found that the APOE- e4 gene carriers in the completion of a simple memory task more brain resources to be used, and two years later,[link widoczny dla zalogowanych], the two follow-up survey found that the extent of brain involvement is negatively correlated with verbal memory. Thus, AD patients may show before the onset of certain cognitive and brain dysfunction. Arai, also cited in the proposed T-protein in cerebrospinal fluid (tauprotein) content can be used to diagnose AD, especially early detection of mild AD. 3j Although the detection method is not mature, but the idea is quite correct. Because if we can predict AD and the early use of appropriate interventions. 65 years old will greatly reduce the incidence. We


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