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 Wysłany: Pon 14:45, 28 Lut 2011 Temat postu: mbt scarpe prezzi Qi down decoction on chronic vir |
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,[link widoczny dla zalogowanych]
Tang Qi Jiangzhuo impact of chronic viral myocarditis MMP1/TIMP1
Drug treatment group and model group, mice of a 1mRNA myocardial tissue levels of MMP, the last 20d than at the same time after infection, the model group,[link widoczny dla zalogowanych], with statistical significance. Treatment groups compared with the control group,[link widoczny dla zalogowanych], no statistical significance. Table 1. Table 1 MMP in myocardium of mice in each group expressed a 1mRNA comparison (mean absorbance value, larvae ±) MMP-1 control group,[link widoczny dla zalogowanych], model group medicine group medicine group 5d035 ± 0.2O0.55 ± 0.2ln46 ± Wang 18n48 ± n19l0d0. 4l ± 0.170.78 ± 0.240.61 ± 0.140.57 ± 0.17 last 20d0.43 ± O. 12 ★ 0.96 ± 0.420.58 ± 0.17 ★ n59 ± nl5 ★ 30d0.49 ~ 0.250.75 ~ 0.380.47 ~ 0.200.45 ~ 0.17, the number of days 40dn39 ± mouth 0.1843 ± n16n42 ± n110.39 ± O. 2450d0.44 ± 0.170.42 ± 0.110.39 ± 0.130.43 ± 0.0960d0.38 ± 0.160.37 ± 0.120.37 ± 0.100.39 ± 0.14 Note : Compared with model group,[link widoczny dla zalogowanych], P <0.05. 2.2 mice in each group the level of myocardial expression of TIMP 1mRNA compared a control group and model group, after the last infection 30d, 40d, 50d, 60d is lower than the same time model group, the t test, significantly different group of mice medicine 1mRNA myocardial TIMP levels in the last one after infection 50d, 60d is lower than the same time the model group, with statistical significance, western medicine group were myocardial tissue TIMP ~ 1mRNA level of infection in the last 60d, lower than the same time the model group, the t test, significant difference. Treatment groups compared with the control group, no statistical significance. Table 2. Table 2, mice in each group the level of myocardial expression of TIMP compare a 1mRNA (mean absorbance value, ± s) MMP-1 control group, model group medicine group medicine group 5dO. 24 ± 0.100.32 ± 0.160.28 ± 0.170.30 ± 0.1110d0.28 ± 0.160.49 ± 0.250.35 ± 0.190.36 ± 0.14-=} . , 20d0.36 ± 0.150.52 ± 0.180.39 ± 0.170.34 ± 0.25:30 d0.38 ± O. 070.59 ± 0.220.4l ± 0.170.39 ± 0.21 Add d0.37 ± 0.1300.73 ± 0.170.50 ± 0.230.49 ± 0.2550d0.36 ± O. 190.89 ± 0.330.54 ± 0.2l0.58 ± O. 1560dn41 ± 0.150.74 ± 0.280.47 ± 0.17n46 ± n21 Note: Compared with model group, P <0.05. 3 to discuss the study, 7d after the last infection, the mice showed myocardial MMPsmRNA transient expression. At 20 ~ 30d reached the peak, MMP ~ 1 may reflect the high expression of acute myocarditis, myocardial metabolism of collagen degradation activity, causing damage to collagen network, and its upregulation may be caused by myocarditis, acute heart dysfunction of one of the factors related 【cytokine TNF-o, IL-1 can affect the expression of MMPs, the infected mice with the last time 5 ~ 10d, TNF-o 【peak expression levels, which may be related to MMP-lmRNA transient expression.
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