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 Wysłany: Nie 12:54, 20 Mar 2011 Temat postu: Lomefloxacin hydrochloride capsules 2 cases of pho |
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Lomefloxacin hydrochloride capsules 2 cases of photosensitivity caused by
Phototoxic skin reactions, such as 1 week after treatment by the incandescent light or direct sunlight, exposure to warm water,[link widoczny dla zalogowanych], there may be skin itching, redness, swelling, severe cases blisters and ulceration after the formation of erosion or ulceration. Phototoxic reactions such as the strong, anti-allergy treatment given to relieve symptoms, usually mild cases can be self-healing, the individual light serious drug reactions, need to actively symptomatic treatment. Photosensitizer completely metabolised in the body needs a month's time. 2.2 Chemical structure of lomefloxacin hydrochloride in its prone to cause photosensitive reactions lomefloxacin hydrochloride carbonyl benzene molecule chemically unstable, the bright light, very easy to accept after the photon, when the oral absorption of biochemical substances in the body after exposure to induced photodynamic reaction, destruction of cell structure caused by a series of photosensitive reactions. Once again taking the drug of photosensitive reactions occurred storage conditions Drug treatment clinic site visits, found that poor storage environment,[link widoczny dla zalogowanych], drug prolonged exposure to sunlight, 2 cases of photosensitive reactions from a clinic in the same environment is closely related with the drug store. Access to the information of the sand stars on the chemical structure of drugs have a carbonyl group, the drug label instructions also required from light, which suggested the grassroots and drug supervision, inspectors should be more drugs on the sand to be concerned about the star, we must urging the operators, and use according to the instructions of the storage requirements of storing drugs in order to prevent the environment from the storage does not meet the requirements of the adverse reactions. 2.3pH value of the drug metabolites in the body such as the white political allegiance proved by experiments lomefloxacin hydrochloride buffer solution at pH values of 5.08-9.40 in the light most unstable in the pH value of 2.02 ~ 5. 9.41 I1.10 07 and a buffer solution of a relatively stable to light. Therefore, physicians in the use of lomefloxacin hydrochloride, adjust the appropriate pH, helps to reduce the incidence of adverse reactions similar. 2.4 Drug Metabolism and Physical lomefloxacin hydrochloride capsules completely absorbed after oral administration, bioavailability of 90% to 98%. Fasting 1:3 single serving 400mg, 1.5h after the peak plasma concentration reached (C ...) 3.0-5.2mg · L ~. This product is widely distributed in the body, tissue penetration is good, in the skin, sputum, tonsils, prostate, gallbladder, tears, saliva and gingival tissues such as the drug concentration at or higher than plasma concentrations, blood half-life than f Shaw (cII, B) is about 7-8h. It is mainly excreted through the kidneys, approximately 48h after the administration of drugs may be the prototype from the discharge of urine drug delivery for 60% to 80%, only a small amount (5%) in the body metabolism, biliary excretion of about 1O%. The product of less mainly by metabolism in vitro metabolism. 2 cases of adverse reactions were older patients (greater than 55 years). Suggests that the physician in patients given older drugs should be careful of sand stars, especially of liver and kidney disease should take into account their metabolic activity. 3 Some of the discussion of adverse drug reactions is difficult to avoid, and some can be avoided, photosensitive reaction led to lomefloxacin hydrochloride side effects, we propose: (1) treatment when patients are required to detail their history of allergies,[link widoczny dla zalogowanych], MD or a history of adverse drug reactions, avoid idiosyncratic adverse reactions resulting from; (2) The lomefloxacin hydrochloride mainly by renal metabolism,[link widoczny dla zalogowanych], recommended for the elderly, children,[link widoczny dla zalogowanych], especially infants observed during treatment should be strengthened; (3) doctors in the use of injection lomefloxacin hydrochloride, pay attention to control the pH value, effectively reducing the light of lomefloxacin hydrochloride degradation products; (4) in drug transport, storage process, the proposed requirements should be strictly according to the instructions of the dark to avoid the hydrochloric acid Lomefloxacin photolysis.
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