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Dołączył: 13 Gru 2010
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 Wysłany: Wto 22:57, 11 Sty 2011 Temat postu: Insulin resistance in NIDDM patients with hyperten |
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Insulin resistance in NIDDM patients with hypertension and dyslipidemia
Prevalence of blood pressure similar level of 48.1 and abroad, significantly higher than the general population, prevalence of hypertension of 7.7 ~ 10.5. NIDDM in different age groups compared the prevalence of hypertension was found that middle-aged NIDDM hypertension prevalence of 28.0, to the elderly has been a marked increase in pre-46.2,[link widoczny dla zalogowanych], while the old age,[link widoczny dla zalogowanych], up to 54.1. In addition, the hypertension group than in non-hypertensive group significantly increased BMI and obesity, hypertension accounted for 47.4, only 25 instead of hypertension. o, that hypertension of obesity on NIDDM has a direct impact. \role in vascular smooth muscle cells through calcium influx,[link widoczny dla zalogowanych], and enhance blood vessel flexibility, increase peripheral resistance; promote renal sodium and water reabsorption; trigger mechanisms such as stimulation of sympathetic activity in hypertension:. This group had a higher blood pressure observed in fasting insulin levels,[link widoczny dla zalogowanych], insulin sensitivity index method to reduce Lee, indicating more severe insulin resistance and hypertension. This phenomenon is adjusted for age and body mass index of these two factors still exist, the sensitive index hypertensive group, the number of amendments were 5.045 ,[link widoczny dla zalogowanych], non-hypertensive group was 4.551 (P <o.001), which reflects one aspect of the pathogenesis of insulin resistance in hypertension may play an important role. dyslipidemia of insulin resistance is the primary factor, both both are risk factors of coronary heart disease. This study shows that hypertension is more severe lipid disorders, especially TG, aPOB significantly higher, HDL-c were significantly reduced, aPOA + I declined (not reach statistical significance). Some studies that lead to hyperinsulinemia, insulin resistance, which promote liver TG synthesis and very low density lipoprotein, and to lipoprotein activity 'decreased, TG clearance is also reduced, resulting in high TG blood. Insulin resistance also enables the liver lipase activity was enhanced to promote high-density lipoprotein degradation, the reduction of plasma high density lipoprotein. This article shows NIDDM with hypertension is more severe when the degree of insulin resistance, and more with obesity and dyslipidemia, which have greatly increased the incidence of coronary heart disease risk, consistent with the hypothesis Reaven. Therefore, the prevention and treatment of these patients should pay attention to insulin resistance, coronary heart disease risk factors of the overall correction.
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