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 Wysłany: Czw 5:12, 26 Maj 2011 Temat postu: Impact of DNA Errors During Reproduction; During C |
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Maintaining DNA Integrity During the Process of Cell Replication
The DNA-damaging environmental conditions that happen include: smoking, ultra violet from over-exposure to the sun, stress,[link widoczny dla zalogowanych], starvation, pesticides, pollutants,[link widoczny dla zalogowanych], the diet of parents and grand-parents, and exposure to the social environment. The diseases caused from this damage include: obesity, heart-disease, diabetes, additional occurrence of disease, and unintended statement or silencing of genes. This damage may happen during: fetal development; the initial developmental phase later birth, and by whichever time throughout one's lifetime.
Defense Against Epigenomic Environmental Damage
The cell replication process itself is prone to error at the rate of from one error in ten thousand to one error in one hundred million gametes. The rate of mutations deserving to errors has been estimated by the number of mutations base at different loci in the genome. Neurofibromatosis disease is caused by a spontaneous dominant mutation at the rate of one in 10,000 gametes. Huntington's disease mutations have been found to be lower than the rate for Neurofibromatosis. Thus, the alter mutation rates for alter genes suggests that definite situations of the genome are extra prone to damage that other places. (DNA Replication Fidelity JBC The Journal of Biological Chemistry” Accessed 29 June 2010).
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An forcible defensive diet that promotes appropriate methylation of DNA and acetylation of histones, shows which foods invest the needed nutrients and what is accomplished:
One may vindicate opposition the effects of environmental damage to the epigenome which affects cell replication, by several manner. One is by emulating a healthy diet that is wealthy in methyl donating nutrients. The other is to lest action that causes damage to the epigenome: over-exposure to ultra violet rays from sunlight; smoking; expense of excessive alcohol; eating fatty foods; granting one's ego to suffer undue stress; not obtaining sufficient discipline; using pills; and living in an over-polluted surroundings.
It namely absolutely required namely the integrity and stability of DNA be maintained in every and every alive compartment during the process of replication. If DNA is damaged along environmental elements,[link widoczny dla zalogowanych],[link widoczny dla zalogowanych], abrupt evolution and the cause of ailment may outcome, unless this harm namely repaired. For instance, undue exposure to ultra violet radiation from sunlight will cause damage apt DNA. Tobacco cloud can cause mutations in lung cells which will cause lung malignancy. DNA is subject apt oxidative damage by free radicals. It has been estimated that an individual cell may suffer up to one million DNA alterations per daytime. (DNA Damage and Repair SciTable Acessed 29 June 2010).
Protecting the Epigenome by Eating a Defensive Diet
The person cell replication process has been shown to be adversely affected by environmental conditions which likewise influence the epigenome. These adverse conditions cause errors to occur during the replication of cells, over and on the natural rate of error which occur during the replication of cells of gametes during forgery. These errors are the original etiology because maximum if necessary always important diseases that plague the human body. This discovery is mysterious,[link widoczny dla zalogowanych], and will change the way that medical science and dietary pharmacology are practiced now and forever.
It is not only likely yet it is strongly recommended that one eat a diet which nurtures, protects, strengthens and ensures that one's genome is sufficiently methylated, thus silencing adverse or retarded genes and preventing the occurrence of disease and harmful remedial conditions. A diet tall in methyl-donating nutrients (folic acid, B vitamins and SAM-e (S-Adenosyl methionine) aids to ensure that the genome is properly and sufficiently methylated, to quiet harmful genes.
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