veoexrmpzt
Dołączył: 21 Lut 2011
Posty: 371
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Skąd: England
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 Wysłany: Wto 10:43, 22 Mar 2011 Temat postu: ghd italia lmn tso wnhq sfa |
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Low-dose immunosuppressive treatment of steroid-dependent asthma, 40 cases
7 cases, 13 females, aged ≤ 1,[link widoczny dla zalogowanych], 1-year-old 3 years old in 15 cases, 17 cases> 3 years old in 8 cases. When treatment were hoarseness, cough,[link widoczny dla zalogowanych], sore throat, such as performance, severe symptoms appear three depressions (or four concave sign), and other symptoms of laryngeal obstruction. Number of cases between the two groups, sex, age, disease duration,[link widoczny dla zalogowanych], clinical manifestations, there was no significant difference (P> 0.05). 1.2 Method Two groups of patients were treated with the same comprehensive and general symptomatic treatment. The treatment group received methylprednisolone (brand name: methylprednisolone, 法玛西亚普 strong Ltd, batch number: 0681) 1-2mg · ks · times ~ ,6-8h, every time 30rain infusion over time. Control group was given intravenous dexamethasone 0.25 ~ 0.5mg · ks · times ~ ,6-8h again. Two groups of patients were observed in 6-8h. Significant bacterial infection select the appropriate antibiotics according to pathogens. Clinical criteria of 1.3 markedly: 23h hoarseness significantly improved symptoms of laryngeal obstruction, looking better, eating can be quiet and rest: Effective: 23h hoarseness improved, laryngeal obstructive symptoms have eased, looking improved,[link widoczny dla zalogowanych], can eat and rest. Invalid :2-3h symptoms no improvement, or even worse,[link widoczny dla zalogowanych], can not eat and rest. 1.4 Statistical analysis using chi-square test. 2 results of two groups of patients for efficacy evaluation by the hand. Treatment group, 32 cases markedly effective in 19 cases (59.3%), 10 cases (31.3%) and 3 cases (9.4%); control group, 40 cases markedly effective in 10 cases (25. 0%), effective in 12 cases (30.0%), invalid l8 cases (45.0%). = 9.26, P <0. O1, the difference was statistically significant. Patients were taken to hospital received an invalid or other symptomatic treatment. Two groups of patients were no side effects. 3 Discussion / |, JL acute laryngitis caused by a virus, mostly in primary bacterial infections are rare. By / |, JL resistance is low, narrow throat, mucous membranes and soft, rich lymphatic vessels, submucosal tissue loose, imperfect development of laryngeal cartilage, coupled with poor expectoration cough reflex, vocal cord edema lmm at the time, you can area of the airway decreased by 65%, so / |, JL prone to laryngeal obstruction than adults, and often occur at night. / |, JL acute laryngitis at the same time one of acute laryngeal tracheal bronchus of a pneumonia. Symptomatic treatment of the disease must be strengthened. Previous general processing with oral, intravenous long-term glucocorticoids. Wide range of pharmacological effects of methylprednisolone and its anti-inflammatory effect is 5 times of hydrocortisone on the human immune system has a strong inhibitory effect, with anti-lipid peroxidation, lysosomal membrane stability, inhibiting the release of proteolytic enzymes, increased local blood flow and promote the role of calcium and other relocation [, advantages are: ① no activity of adrenal cortex hormones; ② no fluorination, degradation of the small muscles of the drug; ③ small inhibitory effect on pituitary-adrenal; ④ short biological half-life L3 .4 J. Dexamethasone is a long-acting hormones, such as the continuous application of a few days, its biological role will be increasing day by day, easily lead to serious side effects [Citation. The efficacy of methylprednisolone in the treatment group was significantly better than the effect of dexamethasone (.] F2 = 9.26, P <0.O1). Therefore, methylprednisolone can be used as the drug of choice in children with acute laryngitis, but should pay attention to whether their application time and long-term side effects.
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