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Dołączył: 13 Gru 2010
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 Wysłany: Śro 15:43, 02 Mar 2011 Temat postu: Borderline ovarian tumors by flow cytometry DNA pl |
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Borderline ovarian tumors by flow cytometry DNA ploidy analysis of the clinical significance
DNA ploidy analysis can be shown to determine the prognosis of borderline ovarian tumors. 1 Data and methods of borderline ovarian tumors of 31 paraffin-embedded tissue. 3t cases were taken from patients with borderline ovarian tumors surgical resection specimens, including 21 cases of serous fluid of 10 patients + fools; FIGO stage: I fell on 28, Ⅱ toward the 3 {average age of patients was 46.7 years (21 ~ 8 years old) were followed up 27 cases with complete data. Paraffin-embedded tissues of benign ovarian tumors 30, respectively, 3O patients with benign ovarian tumors from patients with surgical specimens, including serous and mucinous,[link widoczny dla zalogowanych], n = 15 patients with an average age of 3.8 years (24 to 61 years). Determination Methods: Tumor cell-rich paraffin wax block before each cut t 4um sections 2 to H-E staining, to further clarify the diagnosis of choice drawn by a single small roar suspension was prepared, PI staining. Ah FACStar-based flow cytometry. Paraffin-embedded normal ovarian tissue as the external standard, coefficient of variation to the minimum fine for each of 10 specimens measured roar. DNA index (DNAIndex, DI) as aneuploidy (3 - / (3 - peak channel values were diploid G. / (3 -. The ratio of peak to average channel value, when the DNA histogram is only one G / G . peak time for the DNA diploid; if obvious two or more G. / G peak (DI> 1.1O) +, and subsequently the corresponding period of S phase and the GM DNA aneuploid. 2 Results 30 patients with benign ovarian tumors were DNA diploid. 31 fell in the borderline ovarian tumors, 26 cases were DNA diploid, 5 patients (I6) for the DNA aneuploid (mucus live in 2 cases, 3 cases of serous) . I ~ 8 years of follow-up,[link widoczny dla zalogowanych], 26 patients with DNA diploid borderline ovarian tumors, 3 cases were lost. remaining 23 cases had no recurrence; j Fu cases of DNA differences in the body of borderline ovarian tumors, t cases were lost 2j 2 patients after surgery and months of recurrence of 38 months, more than 2 patients without signs of recurrence (follow-up, asked for less than 2 years.) .30 patients with benign ovarian tumors had no recurrence in follow-up. 5 Discussion Majesty the junction of ovarian tumors After surgery, most patients do not give any assistance even if the treatment is also for many years without recurrence, but some patients showed a higher degree of malignancy. For such patients, if given proper postoperative management,[link widoczny dla zalogowanych], may improve the prognosis , for which no further studies scholars, but different views. Kaefn reported 64 cases of borderline ovarian tumors, serous and Gu solution of DNA aneuploidy rates were 47 + l5 l5 and case follow-up results of DNA Majesty aneuploid serous tumors in 3 cases and the I8 patients with DNA aneuploid tumors, revolves around all of them liquid, and died of ovarian cancer recurrence. This group of 23 patients DNA diploid borderline ovarian tumors were followed up for 1 to 8 No cases of recurrence + and DNA aneuploidy borderline ovarian tumors were 2 cases after 2 months and 38 months recurrence. This tip of the DNA aneuploid borderline ovarian tumors, patients should be put in place appropriate adjuvant treatment measures to reduce the recurrence rate. (19,969,[link widoczny dla zalogowanych],702 Received) and smart growth and development of children without exception. born children in this group received dexamethasone before his mother cypress amount for each 3mg,[link widoczny dla zalogowanych], Total】 ~ 3 times. Review the literature, the application of animal experiments cypress dose dexamethasone, which is about 10 times the human clinical dosage on behalf of the physiological and neurological development impact. 4
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