veoexrmpzt
Dołączył: 21 Lut 2011
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 Wysłany: Nie 12:41, 06 Mar 2011 Temat postu: belstaff espana eal rpa heqk xpt |
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Indapamide sustained release tablets tablets with Levamlodipine isolated systolic hypertension on the efficacy and safety of
When the. Now widely recognized that diuretics can reduce the incidence of hypertension in stroke and reduce cardiovascular events and lower mortality, which is recommended by international guidelines of hypertension. Indapamide sustained release tablets (1.5mg) is a new type of low-dose preparations, and general preparations indapamide (2.5mg) compared to the occurrence of hypokalemia, hyperuricemia and other adverse reactions reduced, but the biological effectiveness did not decline. Studies have shown that antihypertensive drug trough to peak ratios above 50%,[link widoczny dla zalogowanych], taken once a day can make the step-down performance to maintain 30h, can significantly reduce systolic blood pressure, and therefore more suitable for the elderly ISH. The drug also can reverse left ventricular hypertrophy also reduce the role of microalbuminuria. Reported in the literature, the use of other drugs when blood pressure is not standard, to indapamide sustained release tablets can buck standard J. Therefore,[link widoczny dla zalogowanych], ISH is the ideal drug for the treatment of old age. Levamlodipine is a new long-acting dihydropyridine antihypertensive drugs, amlodipine L for the isomers,[link widoczny dla zalogowanych], because in addition to the D-body,[link widoczny dla zalogowanych], so that greatly reduced side effects, and their calcium antagonistic activity is dextral body of nearly 1,[link widoczny dla zalogowanych],000 times. Trough to peak ratio of antihypertensive effect of its high], biological activity for a long time, step-down time can be maintained 24h, for the same drug in the longest half-life and bioavailability of most antihypertensive drugs. It does this by blocking cardiac and vascular smooth muscle cells by extracellular calcium ions into the cell membrane calcium channels within cells, play a direct relaxation of vascular smooth muscle and anti-hypertensive effect. Also has anti-platelet aggregation, oxidative stress, anti-atherosclerosis and protection of endothelial cells and other effects. Levamlodipine film can be highly selective expansion of coronary artery, renal artery and cerebral arteries, on the metabolism of neutral, which is particularly suitable for angina pectoris associated with coronary heart disease, cerebrovascular disease and diabetes in elderly patients with ISH. In this study, two groups of lipids, glucose, uric acid, electrolytes and other blood biochemical indexes and changes in heart rate did not find significant differences compared, indicating that the two drugs on the metabolism and sympathetic activity in small. However, antihypertensive effect, the single-compliance rate with two antihypertensive drugs is still limited, suggesting that combination therapy still need to step-down standards. In conclusion, indapamide sustained release tablets and Levamlodipine systolic blood pressure and pulse pressure in older films reduce a significant clinical effect, antihypertensive effect similar to maintain a long time, tolerance and compliance is good. Both can be used as the basic drug elderly patients with ISH the long-term use. 4
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