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 Wysłany: Czw 14:40, 03 Mar 2011 Temat postu: asics tiger shoes STK15 gene silencing lead to can |
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STK15 gene silencing led to stagnation of gastric cancer cell division
8h. SIXI5 group MKh45 towel cellular control of DNA Tuo cell saddle,[link widoczny dla zalogowanych]! H ah increased C silent genes Figure 2bq'KI5 MKN45 cell cycle distribution after the change in the towel on Health Divination cells was significantly lower than the control siRNA group (4% vs 37%,[link widoczny dla zalogowanych], x = 97.75.P (0.01) .. Ⅱ confocal microscope changes in cell structure was found both in the pre-STKl5 a group of cells or the medium term,[link widoczny dla zalogowanych], its centrosome and spindle structure are more blurred,[link widoczny dla zalogowanych], while the control siRNA structural integrity of the two groups and clear (Figure 3). 4. siRNA targeting the role of genes after STKI5, MKN45 cell proliferation was significantly lower: Mrr Act III said, STK15 rate of gastric cancer cell proliferation was significantly lower than the control siRNA group ( 96h £ = 3.44, P <0.05; 4) sTKI5 is a class of widely present in eukaryotic cells in the serine / threonine kinase involved in cell cycle in normal cells, G / M transition, through the micro- tube nuclei Promotion Centre raised the Son Gang maturation and microtubule nucleation. to ensure that bipolar spindle formation and maintenance of l, to ensure equal distribution to the two sub-chromosome cells. Therefore, inhibition of their expression may damage cells silk sirNA chemical synthesis of high respect, specific characteristics, we set different concentrations of siRNA by transfection of MKN45. Display siRNA concentration Io0nmol / L, the O effectively STK15 gene silencing (role 48Ii.STKI5mRNA and protein were reduced by 89. 54% and 57.18%). to exclude the liposome and siRNA cells and the activity itself may be the impact, we also designed a three-Lan Nie type type exhausted with 2 IH 35 Yu Yan c a promise made head 3sEKI5 ix JL Zuohua MKN45 switch 48h Free pox McNair even mJL as do marrow, # of cells twisted TM0 dragonfly turn nJ 』Ⅲ bleed at the nose ten MIIrA muscle siRNA Ⅲ f at M leg touch rm moisture brown meter dig clear. B A Ⅲ NA actinium rMIIlll ~ ll body ten drainage of scraping Kou Jing Ao eleven temporary pregnant.: 5m ten M head cell. NIE T lung vessels with slave station over terror goblets boat; D: I5 site TM ten Shí n1 him, such as the ten-color 6 panel row,-J% Xun fuzzy ∞ l Chung hammer drill _ I (h) Head 4M13 Katayama made the evaluation of such inhibition Sq3 ~. I5 convergence of the expression of cho cells under arrest, / M _ like the nearby community. that S'IK15 p53 protein can be phosphorylated. promote rMtIm2 3 protein mediated lack of Li t solution of surrender. less D r.53, r mediated marrow cells before the split view Sidan mechanism to promote cell Yin of the process; also were found to deposit cell / M transition and STKI5i 【thin acidification another I, carbuncle-based travel products BRCAI suppressing protein. that When cells (; / M conversion-like drawer required: r of the other thousands of shows, TKI5 and centrosome maturation Ningqie {= l1 cover, the number of centrosome maturation inhibition Srl'KI5 bat features a close relationship with the mourning Xiu barrier negligent spindle formation , S'IKI5 Che M enzyme in the cell into flames after eight positioning j. Lanna section through the spindle on the spindle Tong escape cover the blue and white m} 『1: dyncin, F to power. makes the spindle to maintain a very strong generation cartridges tension to ensure that the chromosome separation in the post-reverse friends. suppression S'I, KI5 lead to the formation of strong shake spindle stained with separation barrier failure Ha . A l 『. maturation, bipolar spindle formation and maintenance of small i-sheets or missing, once the function of inhibition. L system into cells may be damaged. led to stagnation in the (final or M threat period. This explains Feng Yin a police inspection of the ship to the phenomenon: the jl'K15 expressed by Norway, the central body of technical shrinking hammer {Ping structural damage. so that more cells in the pre-crack obituary. can not enter the island playing a full role bipolar spindle but can not speak medium-term, resulting in a decrease in the mid fine with standstill rM from the U shape of the cells were round: As I reached sFKI5 inhibited cell f / M phase transition suppressed. cell Zheng Delay]: G / M nearby. was G: of DNA homes, the 『. role in the final performance of MKN45 proliferation slowed down. of our experiments confirmed that the small cells J STK15 may shake the stomach of a good target for the dry dam. annoyed with the call may be guilty of the stomach sliding treatment provided new clues r
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