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 Wysłany: Śro 22:47, 06 Kwi 2011 Temat postu: Aconitum alkaloids in traditional Chinese medicine |
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Aconitum alkaloids in traditional Chinese medicine mainly gender metabolites in rabbit urine
.) The analysis of MS data and control [4] in the compound, identification of M 16. O. Demethylaconitine second base (16 a O-demethylbenzoylaconine), which under the action of the enzyme aconitase in the base of the 16 sub-methoxy-methyl-off increase in the formation of hydroxy metabolites water-soluble. Excimer-ion m/z500 (M) compounds,[link widoczny dla zalogowanych], in which the soft ionization produced under test conditions m/z468, 450,418 three main fragments, respectively, M has lost part of the methanol, water, and to lose a member of a member caused by methanol (Table 1). Spectral data of the compound the compound name in literature are basically the same contrast J, identified as aconitine of the original base (Aconine), aconitine times that under the action of alkali in the hydrolytic enzyme acid ester hydrolysis, while the alkane skeleton Aconitum release a water-soluble free hydroxyl stronger, less toxic metabolites. Excimer-ion m/z632 (M) and aconitine lose a molecular weight of the metabolites of methyl 631 (+ days) consistent. M in the test conditions of soft ionization mass spectrometry by the multi-level were detected m/z572, 540,512 three main fragments, respectively, M should have lost part of acetic acid, methanol, and a member of a member due to ethylene (see Table 1). The analysis of MS data and control [4] in the compound name, identification M 16.0. Demethylaconitine (16.0.demethylaconitine), which under the action of the enzyme aconitine 16-methoxy-methyl-off increase in the formation of hydroxy metabolites water-soluble. Excimer-ion m/z586 (M) and the loss of part of the acetate metabolism of aconitine in the molecular weight consistent. M test in the soft ionization mass spectrometry conditions were detected by the multi-level to the major fragment ions m/z568 and m/z554, respectively, M has to be part of the water and part of the methanol lost due to (see Table 1). The analysis of MS data and control [4] in the compound name, identification M acetic acid for the removal of aconitine (Deacetateaconitine). M, M is a male and female rabbit urine aconitine poisoning total metabolites. M is only detected in the urine of male rabbits, although the female does not rule out exposure to aconitine in rabbit urine contains aconitine de acetic acid, but not off the acetic acid aconitine aconitine poisoning as forensic indicators. M. M can be used as a male and female forensic poisoning the common indicators of aconitine poisoning.
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