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Dołączył: 13 Gru 2010
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 Wysłany: Czw 13:15, 24 Mar 2011 Temat postu: Abdominal fat in patients with hypertension and di |
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Hypertension and abdominal fat distribution with diabetes
Pressure,[link widoczny dla zalogowanych], diabetes often coexist, is a cardiovascular disease risk factors, insulin resistance is now generally believed that their common pathological basis. Insulin resistance induced hypertension possible mechanisms are: (1) transport of ions inside and outside of cells, resulting in arteriolar smooth muscle in vascular pressure reactivity enhancement substances. (2) increased renal Na / H, 0 in the re-absorption. (3) increased sympathetic activity, increased the plasma norepinephrine. (4) to stimulate insulin-like growth factor-1 secretion, causing vascular smooth muscle cell proliferation. Mechanism of insulin resistance may be caused by diabetes are: (1) the level of organs and tissues of the liver in the resistance, and output increased to produce glycogen, muscle glucose uptake and dispose of; (2) the role of insulin inhibition of lipolysis decreased, increased free fatty acids ; (3) the formation of insulin resistance, abnormal insulin molecular structure; (4) elevated blood glucose and free fatty acid toxicity on cells, the cell function continues to deteriorate. The study confirmed the existing obesity and diabetes may be relevant: (1) increased free fatty acids, increased gluconeogenesis and liver glycogen decreased insulin clearance, leading to hyperinsulinemia and obesity. (2) tumor necrosis factor-a in obesity and insulin resistance in obese patients with type 2 diabetes increased expression in adipose tissue, possibly by accelerating the decomposition of fat, muscle insulin receptor inhibition reduced the role of insulin, leading to insulin resistance. (3) obese peroxisome proliferator-activated decrease in activity,[link widoczny dla zalogowanych], increased insulin resistance. Obesity can lead to hypertension, most scholars believe that an abnormal increase in sympathetic activity through, hyperinsulinemia, high blood sugar status to achieve. See hypertension, diabetes,[link widoczny dla zalogowanych], obesity and other interaction and connection,[link widoczny dla zalogowanych], are closely related to insulin resistance. Insulin resistance can lead to high blood pressure, diabetes and obesity, on the contrary, high glucose and free fatty acids and increase the presence of insulin resistance, and increased free fatty acids in the pathogenesis of hypertension is one of the factors of diabetes. Our study also confirmed that high blood pressure and 48fCONTINUINGMEDICALEDUCATIONv0l-23-N0.6 diabetic patients with abdominal fat accumulation phenomenon, hypertension and diabetes can further increase the accumulation of abdominal fat. Therefore, control insulin resistance, remove the factors that may lead to insulin resistance and improve hyperinsulinemia, hypertension,[link widoczny dla zalogowanych], diabetes, cardiovascular diseases prevention and control has important significance.
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